CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis
Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li
Abstract
We identified a potential CSC regulator and suggest a novel mechanism for how CCL16 governs cancer cell stemness. We propose that CCL16 could be an effective target for breast cancer therapy.
Topics & Concepts
CateninStem cellCancer stem cellBreast cancerCancer researchChemistryWnt signaling pathwayMedicineInternal medicineCancerBiologyCell biologySignal transductionCytokine Signaling Pathways and InteractionsChemokine receptors and signalingCancer Cells and Metastasis