An excipient-free “sugar-coated bullet” for the targeted treatment of orthotopic hepatocellular carcinoma
Feiyang Liu, Lingyan Liu, Dongya Liu, Peng Wei, Wei Feng, Tao Yi
Abstract
An excipient-free nanoformulation is prepared by a reactive oxygen species-responsive prodrug. These sugar-coated bullets selectively target tumor cells, resulting in high in vivo therapeutic efficacy in an orthotopic HCC mouse model.
Topics & Concepts
ExcipientProdrugHepatocellular carcinomaIn vivoSugarChemistryCancer researchIn vitroPharmacologyMedicineBiochemistryBiologyBiotechnologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer Research and Treatments