Tumor-derived Exosomal ENO2 Modulates Polarization of Tumor-associated Macrophages through Reprogramming Glycolysis to Promote Progression of Diffuse Large B-cell Lymphoma
Ruonan Shao, Chengcheng Liu, Ruifeng Xue, Xinpei Deng, Lingrui Liu, Cailu Song, Jindong Xie, Hailin Tang, Wenjian Liu
Abstract
GSK3β/β-catenin/c-Myc signaling pathway to ultimately promote macrophages to an M2-like phenotype, which can promote the proliferation, migration and invasion of DLBCL, suggesting that exosomal ENO2 may be a promising therapeutic target and prognostic biomarker for DLBCL.
Topics & Concepts
Cancer researchMacrophage polarizationBiologyMicrovesiclesDiffuse large B-cell lymphomaPhenotypeLymphomaSignal transductionMacrophageCell biologymicroRNAImmunologyIn vitroGeneBiochemistryExtracellular vesicles in diseaseImmune cells in cancerIL-33, ST2, and ILC Pathways