Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
Nicholas P. D. Liau, Timothy J. Wendorff, John G. Quinn, Micah Steffek, Wilson Phung, Peter Liu, Jia Tang, Flaviyan Jerome Irudayanathan, Saeed Izadi, Andréy S. Shaw, Shiva Malek, S.G. Hymowitz, Jawahar Sudhamsu
Topics & Concepts
KinaseChemistryMutationProtein kinase ACell biologyAllosteric regulationHEK 293 cellsMAPK/ERK pathwayEnzymeBiologyBiochemistryReceptorGene14-3-3 protein interactionsMelanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling