Kaempferol mitigates sepsis-induced acute lung injury by modulating the SphK1/S1P/S1PR1/MLC2 signaling pathway to restore the integrity of the pulmonary endothelial cell barrier
Meijuan Gao, Xuan Zhu, Xiaojin Gao, Hui Yang, Haixia Li, Yuan Du, Jing Gao, Z.K. Chen, Hanpeng Dong, Binsheng Wang, L Zhang
Topics & Concepts
Endothelial stem cellS1PR1Adherens junctionOccludinVascular permeabilityCell biologySepsisHuman umbilical vein endothelial cellSignal transductionCancer researchBiologyImmunologyVascular endothelial growth factor ATight junctionVascular endothelial growth factorEndocrinologyCellBiochemistryVEGF receptorsCadherinIn vitroSphingolipid Metabolism and SignalingInflammasome and immune disordersErythrocyte Function and Pathophysiology