Phosphine-catalyzed [3 + 2] cycloadditions of trifluoromethyl enynes/enediynes with allenoates: access to cyclopentenes containing a CF<sub>3</sub>-substituted quaternary carbon center
Shujie Chen, Guo‐Shu Chen, Jiawei Zhang, Zhaodong Li, Yulei Zhao, Yun‐Lin Liu
Abstract
The first use of trifluoromethyl-substituted enynes/enediynes as non-classical electron-deficient olefins for phosphine-catalyzed [3 + 2] cycloaddition with allenoates is presented.
Topics & Concepts
ChemistryPhosphineTrifluoromethylCatalysisCycloadditionMedicinal chemistryOrganic chemistryAlkylFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisAsymmetric Synthesis and Catalysis