A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner
Yuichi Saito, Tomohiro Yako, Wataru Otsu, Shinsuke Nakamura, Yuki Inoue, Aomi Muramatsu, Yasuhiro Nakagami, Masamitsu Shimazawa, Hideaki Hara
Topics & Concepts
PhagocytosisAutophagyCell biologyGene knockdownAMPKActivator (genetics)Retinal pigment epitheliumPI3K/AKT/mTOR pathwayPhagosomeChemistryBiologySignal transductionReceptorRetinalApoptosisProtein kinase AKinaseBiochemistryRetinal Diseases and TreatmentsGenomics, phytochemicals, and oxidative stressNeuroinflammation and Neurodegeneration Mechanisms