FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma
Usama Khamis Hussein, Sang Hoon Ha, Asmaa Gamal Ahmed, Kyoung Min Kim, See‐Hyoung Park, Chan Young Kim, Keun Sang Kwon, Zhongkai Zhang, Sang‐Ah Lee, Ho Sung Park, Byung‐Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang
Abstract
tumor growth was attenuated with knock-down of SCRIB. Moreover, immunoprecipitation indicates that FAM83H, SCRIB, and β-catenin, form a complex, and knock-down of either FAM83H or SCRIB accelerated proteasomal degradation of β-catenin. In conclusion, this study has found that the individual and combined expression patterns of nuclear FAM83H and SCRIB are prognostic indicators of gastric carcinomas and further suggests that FAM83H and SCRIB are involved in the progression of gastric carcinomas by stabilizing β-catenin.