Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
Verena Panitz, Saša Končarević, Ahmed Sadik, Dennis Friedel, Tobias Bausbacher, Saskia Trump, Vadim Farztdinov, Sandra Schulz, Philipp Sievers, S. Schmidt, Ina Jürgenson, Stephan Jung, Karsten Kuhn, Irada Pflüger, Suraj Sharma, Antje Wick, Pauline Pfänder, Stefan Selzer, Philipp Vollmuth, Felix Sahm, Andreas von Deimling, Ines Heiland, Carsten Hopf, Peter Schulz‐Knappe, Ian Pike, Michael Platten, Wolfgang Wick, Christiane A. Opitz
Abstract
The novel techniques we developed could support the identification of patients that may benefit from therapies targeting TCEs or AHR activation.
Topics & Concepts
Aryl hydrocarbon receptorKynurenineMetaboliteCatabolismMetabolismCancer researchTryptophanChemistryKynurenine pathwayTumor progressionTumor microenvironmentInternal medicineBiologyBiochemistryMedicineAmino acidGeneTumor cellsTranscription factorTryptophan and brain disordersMetabolomics and Mass Spectrometry StudiesGut microbiota and health