Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells
Abigail Allen, David Gau, Paul Francoeur, Jordan Sturm, Yue Wang, Ryan J. Martin, Jodi K. Maranchie, Anette Duensing, Adam Kaczorowski, Stefan Duensing, Lily Wu, Michael T. Lotze, David Ryan Koes, Walter J. Storkus, Partha Roy
Abstract
Based on these findings, we propose a potentiating role for Pfn1 in promoting tumor cell aggressiveness in the setting of ccRCC.
Topics & Concepts
Clear cell renal cell carcinomaStromal cellCancer researchActin cytoskeletonBiologyCell growthCell migrationCellRenal cell carcinomaPathologyMedicineCytoskeletonGeneticsRenal cell carcinoma treatmentRenal and related cancersFerroptosis and cancer prognosis