Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling
Yuqing Zhang, Shushu Wang, Linlin Zhang, Feiye Zhou, Ke-Cheng Zhu, Qin Zhu, Qianqian Liu, Yun Liu, Lei Jiang, Guang Ning, Yufang Bi, Libin Zhou, Xiao Wang
Abstract
The present findings highlight a novel role of HDAC1-PKA-Tph1 signaling in governing β-cell functional compensation by derepressing serotonin synthesis.
Topics & Concepts
AcetylationChemistryCell biologySerotoninFunction (biology)Signal transductionKinaseBiochemistryBiologyReceptorGeneHistone Deacetylase Inhibitors ResearchPancreatic function and diabetesAdenosine and Purinergic Signaling