Neutrophil extracellular traps, released from neutrophil, promote microglia inflammation and contribute to poor outcome in subarachnoid hemorrhage
Zeng Hanhai, Bin Qin, Shengjun Zhou, Jingbo Li, Yinghan Guo, Lingxin Cai, Cao Shenglong, Hang Zhou, Chen Huaijun, Zhuang Jianfeng, Peng Yucong, Xiongjie Fu, Yu Xiaobo, Xiaoxiao Tan, Jianru Li, Chi Gu, Feng Yan, Gao Chen
Abstract
. These results indicate that the existence of neutrophil extracellular traps, released from neutrophils after subarachnoid hemorrhage, can shift microglia toward a more proinflammatory phenotype and contribute to neuroinflammation and poor outcome in subarachnoid hemorrhage.
Topics & Concepts
MicrogliaInflammationNeutrophil extracellular trapsSubarachnoid hemorrhageExtracellularMedicineImmunologyInternal medicineBiologyCell biologyIntracranial Aneurysms: Treatment and ComplicationsTraumatic Brain Injury and Neurovascular DisturbancesNeutrophil, Myeloperoxidase and Oxidative Mechanisms