Silk fibroin production in Escherichia coli is limited by a positive feedback loop between metabolic burden and toxicity stress
Zhengyang Xiao, Alexander Connor, Alyssa M. Worland, Yinjie Tang, R. Helen Zha, Mattheos Koffas
Topics & Concepts
FibroinSILKEscherichia coliMetabolic engineeringBiochemistryFlux (metallurgy)Strain (injury)Amino acidChemistryBiologyEnzymeMaterials scienceAnatomyComposite materialOrganic chemistryGeneSilk-based biomaterials and applicationsViral Infectious Diseases and Gene Expression in InsectsBiochemical and Structural Characterization