6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways
Walaa H. El-Maadawy, Marwa Hassan, Rabab M. Abdou, Riham Salah El-Dine, Tarek Aboushousha, Nebal D. El-Tanbouly, Aly M. El-Sayed
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayInflammasomeAMPKOxidative stressProtein kinase BNephrotoxicityPharmacologyKidneyAcute kidney injuryMedicineInflammationChemistrySignal transductionApoptosisInternal medicineProtein kinase APhosphorylationBiochemistryHeme Oxygenase-1 and Carbon MonoxideChronic Kidney Disease and DiabetesAutophagy in Disease and Therapy