Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors
Žiga Skok, Martina Durcik, Darja Gramec Skledar, Michaela Barančoková, Lucíja Peterlin Mašič, Tihomir Tomašič, Anamarija Zega, D. Kikelj, Nace Zidar, Janez Ilaš
Topics & Concepts
TopoisomeraseDNA gyraseTopoisomerase IVChemistryBiochemistryTopoisomerase inhibitorDNAATPaseEnzymeIC50In vitroGeneEscherichia coliCancer therapeutics and mechanismsNeutropenia and Cancer InfectionsLung Cancer Research Studies