Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
Ewa Paluszkiewicz, Barbara Horowska, Barbara Borowa‐Mazgaj, Grażyna Peszyńska-Sularz, Jolanta Paradziej-Łukowicz, Ewa Augustin, Jerzy Konopa, Zofia Mazerska
Topics & Concepts
ChemistryCytotoxicityStereochemistryPotencyProstate cancerProstatePancreatic cancerMechanism of actionCell growthStructure–activity relationshipG-quadruplexCancer researchMolecular modelDNABiological activityCell culturePancreasMonomerApoptosisBiochemistryCancerIn vitroInternal medicineBiologyGeneticsMedicinePolymerOrganic chemistryDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesHIV/AIDS drug development and treatment