The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways
Yuan‐Yen Chang, Meilin Wang, Jui‐Hsuan Yeh, Shang‐Chun Tsou, Tzu‐Chun Chen, Min‐Yen Hsu, Yi‐Ju Lee, Inga Wang, Hui‐Wen Lin
Abstract
Previous studies have indicated that NaIO 3 induces intracellular reactive oxygen species (ROS) production and has been used as a model for age-related macular degeneration (AMD) due to the selective retinal pigment epithelium (RPE) cell damage it induces.
Topics & Concepts
Reactive oxygen speciesRetinal pigment epitheliumMAPK/ERK pathwayApoptosisCell biologyRetinalIntracellularChemistrySignal transductionPigmentBiologyBiochemistryOrganic chemistryNatural Compound Pharmacology StudiesSynthesis of Organic CompoundsBioactive natural compounds