Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice
Yunfei Wang, Zhengquan Dong, Ruijia Yang, Sujing Zong, Xiaochun Wei, Chunfang Wang, Li Guo, Jian Sun, Haoqian Li, Pengcui Li
Topics & Concepts
OsteoblastIndian hedgehogChondrocyteRUNX2CyclopamineEndocrinologyInternal medicineCellular differentiationParacrine signallingEndochondral ossificationBiologyCell biologyDwarfismHedgehog signaling pathwayCartilageSignal transductionAnatomyMedicineGeneticsGeneIn vitroReceptorHedgehog Signaling Pathway Studiesdental development and anomaliesBone Tumor Diagnosis and Treatments