Asymmetric synthesis of chiral pyrazolo[3,4-<i>b</i>]pyridin-6-ones under carbene catalysis
Qianqian Wu, Jinna Han, Jie Huang, Hailong Zhang, Min Ren, Xiaoxiang Zhang, Zhenqian Fu
Abstract
A structurally diverse set of chiral pyrazolo[3,4- b ]pyridin-6-ones was efficiently prepared in excellent yields with excellent enantioselectivities via N-heterocyclic carbene-catalyzed oxidative [3 + 3] annulation of enals with pyrazol-5-amines.
Topics & Concepts
ChemistryCarbeneCatalysisEnantioselective synthesisCombinatorial chemistryStereochemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods