Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1,3,4-oxadiazole scaffold for combating COVID-19
Fu-Mao Zhang, Ting Huang, Feng Wang, Gui-Shan Zhang, Donglan Liu, Jun Dai, Jianwei Zhang, Qinghua Li, Guo‐Qiang Lin, Dingding Gao, Jincun Zhao, Ping Tian
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ChemistryVero cellCoronavirusProteasesCysteine proteaseCathepsinDeubiquitinating enzymeCathepsin LBiochemistryPeptidomimeticCysteineCovalent bondCathepsin DVirologyCoronavirus disease 2019 (COVID-19)EnzymePeptideIn vitroBiologyInfectious disease (medical specialty)UbiquitinMedicineGeneDiseaseOrganic chemistryPathologyComputational Drug Discovery MethodsSynthesis and biological activityClick Chemistry and Applications