Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology
Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao
Topics & Concepts
AlbuminFusion proteinPharmacokineticsPenetration (warfare)ChemistryPharmacologySerum albuminInterferonBiophysicsAlpha interferonBiochemistryCancer researchBiologyImmunologyRecombinant DNAOperations researchGeneEngineeringMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityGlycosylation and Glycoproteins Research