Controlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation
Ao Hu, Yiyao Pu, Na Xu, Zhongyuan Cai, Ran Sun, Shengxiang Fu, Rongrong Jin, Yingkun Guo, Hua Ai, Yu Nie, Xintao Shuai
Abstract
: A controlled intracellular aggregation system was herein developed, which displayed an aggregation behavior under the acidic tumor microenvironment. The system significantly enhanced MHT effect on tumor cells as well as induced M1 polarization and multinucleated giant cells (MGC) formation of TAM for immune activation. This controlled aggregation system achieved barely tumor growth and metastasis, showing a promising strategy to improve MNPs based MHT on deteriorate cancers.
Topics & Concepts
BiophysicsChemistryIntracellularMagnetic nanoparticlesTumor microenvironmentImmune systemNanoparticleNanotechnologyMaterials scienceBiochemistryImmunologyBiologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsImmune cells in cancer