PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance
Yingxia Zheng, Han Li, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen
Abstract
T cells enriched in lung cancer engaged in tolerogenic effects and may become a therapeutic target in lung cancer.
Topics & Concepts
Cytotoxic T cellCD8Cancer researchCancer immunotherapyMass cytometryPD-L1ImmunotherapyImmune systemBiologyImmune checkpointImmunologyChemistryCell biologyBiochemistryIn vitroPhenotypeGeneCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research