Radical‐Mediated Non‐Dearomative Strategies in Construction of Spiro Compounds
Robert Pawłowski, Patryk Skórka, M. Stodulski
Abstract
Abstract In recent years, spirocyclic compounds have attracted a significant interest in medicinal chemistry due to their considerable biological activities. The general and widely used concept for spirocyclic compound synthesis is related with dearomatization of starting material. However, most of the libraries prepared using this concept comprise structure similarity. Therefore, preparation of structurally distinct libraries comprising varied functionality requires different approaches and that includes non‐dearomative pathways. In given review recent advance in the synthesis of structurally varied spirocycles via radical‐mediated non‐dearomative strategies is discussed. In this context, application of radical initiators or photoredox catalysis is described. The variety of the presented examples indicates the high potential of the visible‐light‐induced methodologies in spirocyclic compound synthesis, which can act as a very efficient green alternative to known procedures, offering mild reaction conditions and high functional group tolerance. magnified image