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Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I

Shashi Jain, Cheng Hu, Jérôme Kluza, Ke Wei, Guiyou Tian, Mădălina Giurgiu, Andreas Bleilevens, Alexandre Rosa Campos, Adriana Charbono, Elmar Stickeler, Jochen Maurer, Elke Holinski‐Feder, Arkadii Vaisburg, Matthias Bureik, Guangcheng Luo, Philippe Marchetti, Yabin Cheng, Dieter A Wolf

2021Cell chemical biology60 citationsDOI

Topics & Concepts

Uncompetitive inhibitorMitochondrionBiologyBiochemistryCancer cellElectron Transport Complex IIn vivoCancerPharmacologyChemistryEnzymeNon-competitive inhibitionRespiratory chainGeneticsCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMitochondrial Function and Pathology
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I | Litcius