Pd/Chiral Phosphoric Acid-Enabled Asymmetric Intramolecular Double C–H Activation Reaction for the Synthesis of <i>P</i>-Stereogenic Benzophosphole Oxides
Shaobai Yan, Zhen Li, Hu XianQi, Shuwei Zhang, Wei‐Liang Duan
Abstract
A Pd-catalyzed intramolecular asymmetric double C–H activation reaction was reported, and a BINOL skeleton-based chiral phosphoric acid (CPA) was identified as a suitable ligand for this transformation. A broad range of P -stereogenic benzophosphole oxides were synthesized in moderate to excellent yield with high levels of enantioselectivity (≤96% ee).
Topics & Concepts
StereocenterChemistryPhosphoric acidIntramolecular forceStereochemistryCombinatorial chemistryMedicinal chemistryCatalysisEnantioselective synthesisOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSulfur-Based Synthesis Techniques