Targeted knockdown of Tim3 by short hairpin RNAs improves the function of anti-mesothelin CAR T cells
Leila Jafarzadeh, Elham Masoumi, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Mohammad Khakpoor-Koosheh, Hosein Rostamian, Farshid Noorbakhsh, Jamshid Hadjati
Topics & Concepts
MesothelinGene knockdownCytotoxic T cellCancer researchChimeric antigen receptorT cellTumor microenvironmentCytokineImmune systemAntigenBiologyChemistryMolecular biologyImmunologyCell cultureTumor cellsIn vitroBiochemistryGeneticsCAR-T cell therapy researchSilicon Carbide Semiconductor TechnologiesGalectins and Cancer Biology