Contrasting behavior between the three human monocyte subsets in dengue pathophysiology
Deepti Maheshwari, Keshav Saini, Prabhat Singh, Mohit Singla, Kaustuv Nayak, Charu C. Aggarwal, Yadya M. Chawla, Prashant Bajpai, Manpreet Kaur, Sivaram Gunisetty, Christiane S. Eberhardt, Rajni Nyodu, Kathryn M. Moore, Mehul S. Suthar, Guruprasad R. Medigeshi, Evan J. Anderson, Rakesh Lodha, S. K. Kabra, Rafi Ahmed, Anmol Chandele, Kaja Murali‐Krishna
Abstract
CD16high nonclassical monocyte subset upregulated key genes involved in vasoconstriction, endothelial barrier stability, and are involved in endothelial patrolling while showing a significant decline from circulation. These findings improve our understanding of monocyte responses in dengue.
Topics & Concepts
MonocyteCD14Dengue feverImmunologyInflammationCCR2EndotheliumPathophysiologyLeukocyte extravasationDengue virusDownregulation and upregulationBiologyMedicineImmune systemGeneChemokineGeneticsPathologyChemokine receptorMosquito-borne diseases and controlViral Infections and VectorsMalaria Research and Control