Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells
Chunliu Mi, Xiang-Xiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-yun Wang
Topics & Concepts
DigitoxinCetuximabCancer researchSTAT3PI3K/AKT/mTOR pathwayChemistryKRASColorectal cancerProtein kinase BEpidermal growth factor receptorApoptosisCancerMolecular biologyBiologyInternal medicineMedicineBiochemistryDigoxinHeart failureCancer, Hypoxia, and MetabolismCytokine Signaling Pathways and InteractionsPI3K/AKT/mTOR signaling in cancer