Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation
Yating Wu, Jianbo Zhu, Haifeng Liu, Hailiang Liu
Abstract
/Bcge) mice before treating them with LA. We tested cognitive ability by subjecting these animals to new object recognition tests and quantified the splenic and whole blood T and B cells. Cognitive ability improved after immune reconstruction and LA treatment, and LA promoted T- and B-cell proliferation in the spleen and whole blood. This study demonstrates that LA, by activating the IL-17 signaling pathway, promotes T- and B-cell proliferation in the spleen and whole blood of mice and improves cognitive ability. Thus, LA may have immune-modulating therapeutic potential for improving cognition.
Topics & Concepts
CognitionCell growthCell biologyPsychologyCancer researchBiologyNeuroscienceGeneticsPharmacological Effects of Natural CompoundsImmune Cell Function and InteractionSystemic Lupus Erythematosus Research