Palladacycle-Catalyzed Olefinic C–P Cross-Coupling of Alkenylsulfonium Salts with Diarylphosphines to Access Alkenylphosphines
Jie Zhu, Yun Ye, Yinhua Huang
Abstract
An efficient olefinic C–P cross-coupling of alkenylsulfonium salts with secondary diarylphosphines is reported. The use of a palladacycle enables the facile formation of a C–P bond at the alkenyl moiety of alkenylsulfonium salts tolerating a wide range of functional groups under mild conditions. This protocol provides an easy access to various alkenylphosphine products in good to high yields with high levels of stereoselectivity (E selectivity).
Topics & Concepts
ChemistryMoietyStereoselectivitySelectivityCatalysisCoupling (piping)Combinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryEngineeringMechanical engineeringSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis