Discovery of the selective and nanomolar inhibitor of DPP-4 more potent than sitagliptin by structure-guided rational design
Bushra Mobeen, Muhammad Shah, Hafiz Muzzammel Rehman, Muhammad Saeed Jan, Umer Rashid
Topics & Concepts
SitagliptinChemistryPharmacologyThiazolidinedioneDrug discoveryRational designDrugOrally activeDipeptidyl peptidase-4Enzyme inhibitorCombinatorial chemistryType 2 diabetesDiabetes mellitusEnzymeBiochemistryIn vitroNanotechnologyMedicineEndocrinologyMaterials scienceDiabetes Treatment and ManagementPeptidase Inhibition and AnalysisEnzyme Catalysis and Immobilization