CroR Regulates Expression of <i>pbp4(5)</i> to Promote Cephalosporin Resistance in Enterococcus faecalis
Sarah B. Timmler, Stephanie L. Kellogg, Samantha N. Atkinson, Jaime L. Little, Dušanka Djorić, Christopher J. Kristich
Abstract
Investigation into molecular mechanisms used by enterococci to subvert cephalosporin antibiotics is imperative for preventing and treating life-threatening infections. In this study, we used genetic means to investigate the functional output of the CroS/R TCS required for enterococcal resistance to cephalosporins. We found that enhanced production of the penicillin-binding protein Pbp4(5) upon exposure to cell wall stress was mediated by CroS/R and was critical for intrinsic cephalosporin resistance of E. faecalis.
Topics & Concepts
CephalosporinEnterococcus faecalisMicrobiologyAntibioticsAntibiotic resistanceBiologyBacteriaGeneticsStaphylococcus aureusAntimicrobial Resistance in StaphylococcusClostridium difficile and Clostridium perfringens researchBacterial Genetics and Biotechnology