Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones and indolin-2-ones
Yani Luo, Tian Tian, Yasushi Nishihara, Leiyang Lv, Zhiping Li
Abstract
)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.
Topics & Concepts
GermaniumChemistryGermanium compoundsCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistrySiliconCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Biological Evaluation