ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis
Jiehui Tan, Rong-chang Cao, Lei Zhou, Zhitao Zhou, Huoji Chen, Jia Xu, Xuemei Chen, Yang-chen Jin, Jiayu Lin, Jun-ling Zeng, Shu-Ji Li, Min Luo, Guodong Hu, Xiao-Bing Yang, Jin Jin, Guowei Zhang
Abstract
These results reveal that ATF6/p53/AIFM2 pathway plays a critical role in acinar apoptosis during SAP progression, highlighting novel therapeutic target molecules for SAP.
Topics & Concepts
ATF6Knockout mouseGene knockdownApoptosisUnfolded protein responseEndoplasmic reticulumCell biologyBiologySmall hairpin RNACancer researchMolecular biologyMedicineInternal medicineReceptorBiochemistryPancreatitis Pathology and TreatmentEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune Regulation