Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases
Paul D. Kruithof, Sergey Lunev, Sheila P. Aguilar Lozano, Fernando de Assis Batista, Zayana M. Al-Dahmani, Jaap A. Joles, Amalia M. Dolga, Matthew R. Groves, Harry van Goor
Abstract
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.