Photoswitchable Bis(amidopyrroles): Modulating Anion Transport Activity Independent of Binding Affinity
David Villarón, Jasper E. Bos, Fabien Kohl, Stefan Mommer, Jorn de Jong, Sander J. Wezenberg
Abstract
High Resolution Image Download MS PowerPoint Slide Toward photocontrol of anion transport across the bilayer membrane, stiff-stilbene, which has dimethyl substituents in the five-membered rings, is functionalized with amidopyrrole units. UV–vis and 1 H NMR studies show high photostability and photoconversion yields. Where the photoaddressable ( E )- and ( Z )-isomers exhibit comparable binding affinities, as determined by 1 H NMR titrations, fluorescence-based transport assays reveal significantly higher transport activity for the ( Z )-isomers. Changing the binding affinity is thus not a necessity for modulating transport. Additionally, transport can be triggered in situ by light.