Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin
Marina Sagnou, Fedor N. Novikov, Ekaterina S. Ivanova, Polyxeni Alexiou, Viktor S. Stroylov, Ilya Yu. Titov, Victor V. Tatarskiy, Murad Vagida, Maria Pelecanou, Аlexander А. Shtil, Ghermes G. Chilov
Topics & Concepts
ChemistryCurcuminP-glycoproteinPharmacologyDruggabilityDoxorubicinK562 cellsMultiple drug resistanceEffluxLipophilicityBiochemistryIn vitroChemotherapyBiologyAntibioticsGeneGeneticsDrug Transport and Resistance MechanismsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery