Anti-tumor activity of polysaccharides extracted from<i>Pinus massoniana</i>pollen in colorectal cancer-<i>in vitro</i>and<i>in vivo</i>studies
Hongqi Shang, Xiangyun Niu, Wenping Cui, Zhou Sha, Cheng Wang, Teng Huang, Ping Guo, Xiangkun Wang, Panpan Gao, Shuyu Zhang, Kai Wei, Rui‐Liang Zhu
Abstract
, PPPS exhibited potent antitumor activity and no observable toxicity in BALB/c nude mice bearing HCT-116 tumors. Most strikingly, PPPS pre-treatment dramatically inhibited the growth of incipient tumors, although not as effectively as in the PPPS-Ther group. Thus, our results suggest that PPPS can be a potential anti-CRC agent, paving the way for developing complex carbohydrates for tumor prevention and treatment.
Topics & Concepts
In vivoApoptosisColorectal cancerCancer researchCell growthIn vitroPolysaccharideMetastasisPinus massonianaCell cycleCellChemistryPharmacologyCancerBiologyMedicineInternal medicineBiochemistryBotanyBiotechnologyGlycosylation and Glycoproteins ResearchNatural product bioactivities and synthesisPolysaccharides and Plant Cell Walls