Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages
Wei Yu, Chunjuan Chen, Wanling Zhuang, Wei Wang, Weidong Liu, Hairong Zhao, Jiaming Lv, De Xie, Qiang Wang, Furong He, Chenxi Xu, Bingyang Chen, Tetsuya Yamamoto, Hidenori Koyama, Jidong Cheng
Topics & Concepts
TXNIPThioredoxin-Interacting ProteinProtein kinase BInsulin resistanceChemistryPI3K/AKT/mTOR pathwayDownregulation and upregulationGene silencingCell biologyOxidative stressSignal transductionCancer researchBiologyInternal medicineEndocrinologyInsulinThioredoxinBiochemistryMedicineGeneGout, Hyperuricemia, Uric AcidPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism