MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony Variants <i>In Vitro</i> within Macrophages and Endothelial Cells during Prolonged Vancomycin Exposure
Thiago Fauerharmel-Nunes, Ronald S. Flannagan, Mariya I. Goncheva, Arnold S. Bayer, Vance G. Fowler, Liana C. Chan, Michael R. Yeaman, Yan Q. Xiong, David E. Heinrichs
Abstract
0.0001 at 24 h). This phenotype could represent one potential basis for the unique ability of PB isolates to adaptively resist vancomycin therapy and cause PB in humans. Elucidating the molecular mechanism(s) by which PB strains form nsSCVs could facilitate the discovery of novel treatment strategies to mitigate PB due to MRSA.
Topics & Concepts
BacteremiaBiologyMicrobiologyIn vitroVancomycinBacteriaAntibioticsImmunologyVirologyStaphylococcus aureusGeneticsAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingAntibiotic Resistance in Bacteria