Reversal of cisplatin chemotherapy resistance by glutathione-resistant copper-based nanomedicine<i>via</i>cuproptosis
Yao Lu, Qingqing Pan, Wenxia Gao, Yuji Pu, Bin He
Abstract
antitumor evaluation shows that the nanomedicine has superior biosafety and potent antitumor activity in a cisplatin-resistant tumor model. Our study suggests that copper-organic complex-based nanosystems could be a powerful toolbox to tackle the platinum-based drug resistance and systemic toxicity concerns.
Topics & Concepts
CisplatinNanomedicineGlutathioneChemotherapyCopperPharmacologyCancer researchMaterials scienceOncologyMedicineChemistryInternal medicineNanotechnologyBiochemistryNanoparticleMetallurgyEnzymeMetal complexes synthesis and propertiesTrace Elements in HealthDrug Transport and Resistance Mechanisms