Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review
Л.М. Михалева, A.I. Davydov, Olga I. Patsap, Elizaveta V. Mikhaylenko, Vladimir N. Nikolenko, Маргарита Е. Неганова, С. Г. Клочков, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch Aliev
Abstract
This review focuses on pathogenesis of endometriosis, its possible biomarkers and role in endometriosis-associated ovarian cancer. We analyzed various databases to obtain new insights, theories, and biomarkers associated with endometriosis. There are several theories of endometriosis development and biomarker changes including atypical forms. A number of studies have attempted to establish specific, reliable biomarkers to help diagnose endometriosis and endometriosis-associated diseases on the basis of different pathogenetic pathways. Nevertheless, despite intensive research extending even to the molecular level, the origin, natural history, malignant transformation, and laboratory management of endometriosis and related diseases are not yet clearly defined. Therefore, early laboratory diagnoses of endometriosis, its atypical form, and endometriosis-associated ovarian tumors are important problems that require further study in the context of advanced therapeutic strategies to provide maximal health benefits to patients.