SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy
Mingyu Liu, Li-Juan Yue, Yingchun Luo, Jing Lu, Guodong Wu, Siqi Sheng, Yuanqi Shi, Zengxiang Dong
Topics & Concepts
Sirtuin 1SUMO proteinHDAC4Cell biologyCoactivatorHistone deacetylaseBiologyAngiotensin IISirtuinPeroxisome proliferator-activated receptorMuscle hypertrophyEndocrinologyInternal medicineTranscription factorReceptorChemistryCancer researchHistoneNAD+ kinaseDownregulation and upregulationUbiquitinBiochemistryMedicineEnzymeGeneCancer-related molecular mechanisms researchSirtuins and Resveratrol in MedicineRNA modifications and cancer