Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
Luke Y. C. Chen, Catherine M. Biggs, Shahin Jamal, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon
Abstract
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
Topics & Concepts
Cytokine stormCytokineCoronavirus disease 2019 (COVID-19)BlockadeCytokine release syndromeInterleukinInterleukin 6ReceptorMedicineCytokine receptorStormImmunologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakInternal medicineVirologyGeographyDiseaseMeteorologyOutbreakInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Inflammasome and immune disorders