Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways
Emily Jamieson, Roxanna Korologou‐Linden, Robyn E. Wootton, Anna L. Guyatt, Thomas Battram, Kimberley Burrows, Tom R. Gaunt, Martin D. Tobin, Marcus R. Munafò, George Davey Smith, Kate Tilling, Caroline L. Relton, Tom G. Richardson, Rebecca C. Richmond
Abstract
, although DNA methylation at some sites might influence lung function via effects on smoking. By using "moloc", we found evidence of shared causal variants between lung function, gene expression, and DNA methylation. These findings highlight potential therapeutic targets for improving lung function and possibly smoking cessation, although larger, tissue-specific datasets are required to confirm these results.
Topics & Concepts
Mendelian randomizationDNA methylationComputational biologyBiologyGeneticsMedicineGeneGene expressionGenetic variantsGenotypeGenetic Associations and EpidemiologyEpigenetics and DNA MethylationNutritional Studies and Diet