Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
A. Jennifer Morton
Abstract
Sleep and circadian disruption affects most individuals with Huntington's disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal models and discuss two key questions: 1) How relevant are such findings to people with HD, and 2) Whether or not therapeutic interventions that ameliorate deficits in animal models of HD might translate to meaningful therapies for people with HD.
Topics & Concepts
Circadian rhythmHuntington's diseaseSleep (system call)DiseaseNeuroscienceAnimal modelDark therapyPsychologyGenetically modified mouseMedicineTransgeneEndocrinologyInternal medicineBiologyGeneticsOperating systemGeneComputer scienceGenetic Neurodegenerative DiseasesCircadian rhythm and melatoninMitochondrial Function and Pathology