An injectable hydrogel with photothermal and chemodynamic therapies for targeted promotion of ferroptosis in oral squamous cell carcinoma
Xu Zhang, Li Mao, Xin Pang, Wanli Wang, Xiaochen Wang, Ze-Liang Shen, Rong-jia Shi, Ya‐ling Tang, Xinhua Liang
Abstract
and ˙OH, and generate repeated high temperatures under photothermal therapy (PTT) for a direct OSCC-killing effect after the loading of PCu and PDA. In addition, the OSCC tissue RNA sequencing suggests that the differentially expressed genes of the CHPP hydrogels exerting the targeted OSCC therapy enrich the ferroptosis signaling pathways significantly. Then, liproxstatin-1 (a ferroptosis inhibitor) was utilized to recover the activation of glutathione peroxidase 4 (GPX4), which can weaken the therapeutic effect of CHPP on OSCC. The CHPP hydrogels are a promising strategy for the treatment of OSCC.
Topics & Concepts
Self-healing hydrogelsPhotothermal therapyHyaluronic acidCancer researchTumor microenvironmentChemistryGlutathioneCD44Cancer cellCellCancerBiochemistryMedicineMaterials scienceNanotechnologyInternal medicineOrganic chemistryEnzymeAnatomyTumor cellsNanoplatforms for cancer theranosticsFerroptosis and cancer prognosisImmune cells in cancer