Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue
Muhammad Zoabi, Lichao Zhang, Tie‐Mei Li, Joshua E. Elias, Scott M. Carlson, Or Gozani
Abstract
substrate of METTL21C and suggest a role for the METTL21C-AARS1 axis in the regulation of protein synthesis in muscle tissue. Moreover, our study describes a straightforward protocol for elucidating the physiological substrates of poorly characterized or uncharacterized PKMTs.
Topics & Concepts
MethyltransferaseMethylationProtein methylationBiochemistryBiologyAminoacyl tRNA synthetaseTransfer RNAEnzymeAlanineAmino acidRNAGeneCancer-related gene regulationRNA modifications and cancerPeptidase Inhibition and Analysis