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Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents

Bassem H. Naguib, Heba A. Elsebaie, Mohamed S. Nafie, Samy Mohamady, Nader R. Albujuq, Aya Samir Ayed, Dina Nada, Ahmed Khalil, Salma M. Hefny, Haytham O. Tawfik, Moataz A. Shaldam

2024Bioorganic Chemistry13 citationsDOI

Topics & Concepts

CoumarinChemistryIn vitroCancer cell linesStereochemistrystatCancer cellCombinatorial chemistryCancerPharmacologyApoptosisBiochemistrySTAT3Organic chemistryInternal medicineMedicineSynthesis and biological activityCytokine Signaling Pathways and InteractionsSynthesis of heterocyclic compounds
Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents | Litcius